The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI
BackgroundTraumatic brain injury (TBI) induces an acute reactive state of microglia, which contribute to secondary injury processes through phagocytic glitter foam vellen action activity and release of cytokines.Several receptor tyrosine kinases (RTK) are activated in microglia upon TBI, and their blockade may reduce the acute inflammation and decr